Work Package Leader: National Research Council (CNR, Italy)
WP3 will investigate the role of intestinal factors in NAFLD/NASH development. Intestinal factors include alterations in intestinal microbiota species and metabolic activities that lead to dysbiosis with host colonocytes and compromised intestinal barrier function as well as alterations in intestinal endocrine factors that adversely influence hepatic metabolic control. These objectives have been distributed between three ESR projects that combine observational studies in both mouse models and NAFLD patients with interventional studies in animal models. Three host institutions are involved in WP3(CNC, IPHYS and CNR).