Work Package Leader: University of Bari Aldo Moro (UNIBA, Italy)
The objective of WP5 is to demonstrate that a change in lifestyle, i.e. promoting physical activity or a change in diet to a Mediterranean type or rich in mushroom extracts improves the NAFLD phenotype. This will be achieved with research on: the effect that regular physical activity may have in the metabolic and mitochondrial profile of NAFLD animal models, dietary changes as a therapeutical approach, as well as use of a mouse model of NAFLD to demonstrate that a diet rich in Panellus serotinus improves mitochondrial function, reduces oxidative stress and lipotoxicity. Three host institutions are involved in WP5 (UPORTO, UNIBA, HMGU).