Peer Reviewed

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Multiplying effects of COVID-19 lockdown on metabolic risk and fatty liver

Shanmugam H, Di Ciaula A, Di Palo DM, Molina-Molina E, Garruti G, Faienza MF, vanErpecum K, Portincasa P.

Multiplying effects of COVID-19 lockdown on metabolic risk and fatty liver. Eur J Clin Invest. 2021 Jul;51(7):e13597.

DOI: 10.1111/eci.13597

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Adiponectin involved in portal flow hepatic extraction of 13C-metacethin in obesity and non-alcoholic fatty liver

Di Ciaula A, Carbone F, Shanmugham H, Molina-Molina E, Bonfrate L, Ministrini S, Montecucco F, Portincasa P.

Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver. Eur J Intern Med. 2021 Jul;89:56-64.

DOI: 10.1016/j.ejim.2021.03.036

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The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Simões ICM, Amorim R, Teixeira J, Karkucinska-Wieckowska A, Carvalho A, Pereira SP, Simões RF, Szymanska S, Dąbrowski M, Janikiewicz J, Dobrzyń A, Oliveira PJ, Potes Y, Wieckowski MR.

The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production. Int J Mol Sci. 2021 Jun 25;22(13):6848.

DOI: 10.3390/ijms22136848

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Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Amorim R, Simões ICM, Veloso C, Carvalho A, Simões RF, Pereira FB, Thiel T, Normann A, Morais C, Jurado AS, Wieckowski MR, Teixeira J, Oliveira PJ.

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells. Nutrients. 2021 May 19;13(5):1723.

DOI: 10.3390/nu13051723

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Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach

Bardallo RG, da Silva RT, Carbonell T, Folch-Puy E, Palmeira C, Roselló-Catafau J, Pirenne J, Adam R, Panisello-Roselló A.

Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach. Int J Mol Sci. 2021 May 19;22(10):5332.

DOI: 10.3390/ijms22105332

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Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?

Di Ciaula A, Passarella S, Shanmugam H, Noviello M, Bonfrate L, Wang DQ, Portincasa P.

Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies? Int J Mol Sci. 2021 May 20;22(10):5375.

DOI: 10.3390/ijms22105375

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Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring

Stevanović-Silva J, Beleza J, Coxito P, Pereira S, Rocha H, Gaspar TB, Gärtner F, Correia R, Martins MJ, Guimarães T, Martins S, Oliveira PJ, Ascensão A, Magalhães J.

Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring. Metabolism. 2021 Mar;116:154704.

DOI: 10.1016/j.metabol.2021.154704

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Anti‐ApoA‐1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

Carbone F, Ciaula AD, Pagano S, Minetti S, Ansaldo AM, Ferrara D, Belfiore A, Elia E, Pugliese S, Ostilio Palmieri V, Montecucco F, Vuilleumier N, Portincasa P.

Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet. Eur J Clin Invest. 2021 Mar;51(3):e13410.

DOI: 10.1111/eci.13410

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Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases

Marques-Aleixo I, Beleza J, Sampaio A, Stevanović J, Coxito P, Gonçalves I, Ascensão A, Magalhães J.

Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases. Antioxid Redox Signal. 2021 Mar 10;34(8):674-693.

DOI: 10.1089/ars.2020.8075

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Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise.

Beleza J, Stevanović-Silva J, Coxito P, Costa RC, Ascensão A, Torrella JR, Magalhães J.

Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise. Eur J Clin Invest. 2021 Feb 13:e13515.

DOI: 10.1111/eci.13515

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Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

Sistilli G, Kalendova V, Cajka T, Irodenko I, Bardova K, Oseeva M, Zacek P, Kroupova P, Horakova O, Lackner K, Gastaldelli A, Kuda O, Kopecky J, Rossmeisl M.

Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity. Nutrients. 2021 Jan 29;13(2):437.

DOI: 10.3390/nu13020437

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The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes

Guerra S, Gastaldelli A.

The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes. Curr Opin Pharmacol. 2020 Dec;55:165-174.

DOI: 10.1016/j.coph.2020.10.016

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New Insights in Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury 2.0: An Updated Overview

Panisello-Roselló A, Roselló-Catafau J, Adam R.

New Insights in Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury 2.0: An Updated Overview. Int J Mol Sci. 2020 Dec 22;22(1):28.

DOI: 10.3390/ijms22010028

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(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle

Molina-Molina E, Shanmugam H, Di Ciaula A, Grattagliano I, Di Palo DM, Palmieri VO, Portincasa P.

(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle. JHEP Rep. 2020 Nov 4;3(1):100203.

DOI: 10.1016/j.jhepr.2020.100203

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Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13C‐isotopomers derived from [U‐13C]fructose and [U‐13C]glucose

Belew GD, Di Nunzio G, Tavares L, Silva JG, Torres AN, Jones JG.

Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U-13 C]fructose and [U-13 C]glucose. Magn Reson Med. 2020 Nov;84(5):2765-2771.

DOI: 10.1002/mrm.28286

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Childhood obesity, cardiovascular and liver health: a growing epidemic with age

Faienza MF, Chiarito M, Molina-Molina E, Shanmugam H, Lammert F, Krawczyk M, D'Amato G, Portincasa P.

Childhood obesity, cardiovascular and liver health: a growing epidemic with age. World J Pediatr. 2020 Oct;16(5):438-445.

DOI: 10.1007/s12519-020-00341-9

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Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response

Simoes ICM, Karkucinska-Wieckowska A, Janikiewicz J, Szymanska S, Pronicki M, Dobrzyn P, Dabrowski M, Dobrzyn A, Oliveira PJ, Zischka H, Potes Y, Wieckowski MR.

Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response. Antioxidants (Basel). 2020 Oct 15;9(10):995.

DOI: 10.3390/antiox9100995

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The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective

Simoes ICM, Morciano G, Lebiedzinska-Arciszewska M, Aguiari G, Pinton P, Potes Y, Wieckowski MR.

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective. Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165834.

DOI: 10.1016/j.bbadis.2020.165834

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Mechanisms for increased risk of diabetes in chronic liver diseases

Svegliati-Baroni G, Gaggini M, Carli F, Barbieri C, Cucco M, Youne R, Rosso C, Bugianesi E, Gastaldelli A.

Mechanisms for increased risk of diabetes in chronic liver diseases. Liver Int. 2020 Oct;40(10):2489-2499.

DOI: 10.1111/liv.14556

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Lytic cell death in metabolic liver disease

Gautheron J, Gores GJ, Rodrigues CMP.

Lytic cell death in metabolic liver disease. J Hepatol. 2020 Aug;73(2):394-408.

DOI: 10.1016/j.jhep.2020.04.001

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Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

Svegliati-Baroni G, Patrício B, Lioci G, Macedo MP, Gastaldelli A.

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH. Int J Mol Sci. 2020 Aug 13;21(16):5820.

DOI: 10.3390/ijms21165820

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Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation

Panisello Rosello A, Teixeira da Silva R, Castro C, G Bardallo R, Calvo M, Folch-Puy E, Carbonell T, Palmeira C, Roselló Catafau J, Adam R.

Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation. Int J Mol Sci. 2020 Aug 9;21(16):5703.

DOI: 10.3390/ijms21165703

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Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR, Pinton P.

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology. Biomolecules. 2020 Jul 4;10(7):998.

DOI: 10.3390/biom10070998

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Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives

Pedriali G, Morciano G, Patergnani S, Cimaglia P, Morelli C, Mikus E, Ferrari R, Gasbarro V, Giorgi C, Wieckowski MR, Pinton P.

Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives. Int J Mol Sci. 2020 Jul 11;21(14):4899.

DOI: 10.3390/ijms21144899

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Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance?

Alemany-Pagès M, Moura-Ramos M, Araújo S, Macedo MP, Ribeiro RT, do Ó D, Ramalho-Santos J, Azul AM.

Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance? BMC Public Health. 2020 Jul 20;20(1):1142.

DOI: 10.1186/s12889-020-09249-5

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Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice

DiNunzio G, Belew GD, Torres AN, Silva JG, Silva LP, Barosa C, Tavares L, Jones JG.

Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice. Sci Rep. 2020 Jul 30;10(1):12852.

DOI: 10.1038/s41598-020-69820-3

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Aging and nutrition. Paving the way to better health

Molina-Molina E, Garruti G, Shanmugam H, Di Palo DM, Grattagliano I, Mastronuzzi T, Portincasa P.

Aging and nutrition. Paving the way to better health. Rom J Intern Med. 2020 Jun 1;58(2):55-68.

DOI: 10.2478/rjim-2020-0005

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Publicly stressing the role of mitochondria in NAFLD with(in) a sports event

Alemany-Pagès M, Tavares R, Varela Amaral S, Barros-Viegas AT, Oliveira PJ, Ramalho-Santos J, Azul AM.

Publicly stressing the role of mitochondria in NAFLD with(in) a sports event. Eur J Clin Invest. 2020 May;50(5):e13234.

DOI: 10.1111/eci.13234

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Inhibition of Receptor-Interacting Protein Kinase 1 Improves Experimental Non-Alcoholic Fatty Liver Disease

Majdi A, Aoudjehane L, Ratziu V, Islam T, Afonso MB, Conti F, Mestiri T, Lagouge M, Foufelle F, Ballenghien F, Ledent T, Moldes M, Cadoret A, Fouassier L, Delaunay JL, Aït-Slimane T, Courtois G, Fève B, Scatton O, Prip-Buus C, Rodrigues CMP, Housset C, Gautheron J.

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. J Hepatol. 2020 Apr;72(4):627-635.

DOI: 10.1016/j.jhep.2019.11.008

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Mitophagy in Cardiovascular Diseases

Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P.

Mitophagy in Cardiovascular Diseases. J Clin Med. 2020 Mar 24;9(3):892.

DOI: 10.3390/jcm9030892

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Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases

Shanmugam H, Molina Molina E, Di Palo DM, Faienza MF, Di Ciaula A, Garruti G, Wang DQH, Portincasa P.

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases. J Gastrointestin Liver Dis. 2020 Mar 13;29(1):99-110.

DOI: 10.15403/jgld-544

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Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Stevanović J, Beleza J, Coxito P, Ascensão A, Magalhães J.

Physical exercise and liver "fitness": Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease. Mol Metab. 2020 Feb;32:1-14.

DOI: 10.1016/j.molmet.2019.11.015

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Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis

Di Palo DM, Garruti G, Di Ciaula A, Molina-Molina E, Shanmugam H, De Angelis M, Portincasa P.

Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis. Nutrients. 2020 Feb 21;12(2):564.

DOI: 10.3390/nu12020564

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Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective

Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C, Pinton P.

Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol. 2020 Feb;98:167-180.

DOI: 10.1016/j.semcdb.2019.05.015

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The role of mitochondria-associated membranes in cellular homeostasis and diseases

Perrone M, Caroccia N, Genovese I, Missiroli S, Modesti L, Pedriali G, Vezzani B, Vitto VAM, Antenori M, Lebiedzinska-Arciszewska M, Wieckowski MR, Giorgi C, Pinton P.

The role of mitochondria-associated membranes in cellular homeostasis and diseases. Int Rev Cell Mol Biol. 2020;350:119-196.

DOI: 10.1016/bs.ircmb.2019.11.002

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Insulin resistance, but not insulin response, during oral glucose tolerance test (OGTT) is associated to worse histological outcome in obese NAFLD

Coccia F, Testa M, Guarisco G, Di Cristofano C, Silecchia G, Leonetti F, Gastaldelli A, Capoccia D.

Insulin resistance, but not insulin response, during oral glucose tolerance test (OGTT) is associated to worse histological outcome in obese NAFLD. Nutr Metab Cardiovasc Dis. 2020 Jan 3;30(1):106-113.

DOI: 10.1016/j.numecd.2019.08.001

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Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis

Belew GD, Silva J, Rito J, Tavares L, Viegas I, Teixeira J, Oliveira PJ, Macedo MP, Jones JG.

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis. J Lipid Res. 2019 Dec;60(12):2050-2056.

DOI: 10.1194/jlr.RA119000354

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Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Simoes ICM, Janikiewicz J, Bauer J, Karkucinska-Wieckowska A, Kalinowski P, Dobrzyń A, Wolski A, Pronicki M, Zieniewicz K, Dobrzyń P, Krawczyk M, Zischka H, Wieckowski MR, Potes Y.

Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease. Nutrients. 2019 Nov 24;11(12):2871.

DOI: 10.3390/nu11122871

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Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

Carbone F, Lattanzio MS, Minetti S, Ansaldo AM, Ferrara D, Molina-Molina E, Belfiore A, Elia E, Pugliese S, Palmieri VO, Montecucco F, Portincasa P.

Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria. Int J Mol Sci. 2019 Nov 27;20(23):5981.

DOI: 10.3390/ijms20235981

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Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment

Molina-Molina E, Krawczyk M, Stachowska E, Lammert F, Portincasa P.

Non-Alcoholic Fatty Liver Disease in Non-Obese Individuals: Prevalence, Pathogenesis and Treatment. Clin Res Hepatol Gastroenterol. 2019 Nov;43(6):638-645.

DOI: 10.1016/j.clinre.2019.04.005

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A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Malik AN, Simões ICM, Rosa HS, Khan S, Karkucinska-Wieckowska A, Wieckowski MR.

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease. Cells. 2019 Oct 8;8(10):1222.

DOI: 10.3390/cells8101222

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Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders

Meneses MJ, Silvestre R, Sousa-Lima I, Macedo MP.

Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders. Int J Mol Sci. 2019 Aug 19;20(16):4049.

DOI: 10.3390/ijms20164049

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Antioxidant Versus Pro-Apoptotic E_ects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Fontes A, Alemany-Pagès M, Oliveira PJ, Ramalho-Santos J, Zischka H, Azul AM.

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease. Int J Mol Sci. 2019 Aug 16;20(16):3987.

DOI: 10.1016/j.clinre.2019.04.005

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Faster Detection of Helicobacter pylori Infection by 13 C-Urea Breath Test. Comparing Short versus Standard Sampling Time

Molina-Molina E, Bonfrate L, Lorusso M, Shanmugam H, Scaccianoce G, Rokkas T, Portincasa P.

Faster Detection of Helicobacter pylori Infection by 13 C-Urea Breath Test. Comparing Short versus Standard Sampling Time. J Gastrointestin Liver Dis. 2019 Jun 1;28:151-161.

DOI: 10.15403/jgld-175

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Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Hackl MT, Fürnsinn C, Schuh CM, Krssak M, Carli F, Guerra S, Freudenthaler A, Baumgartner-Parzer S, Helbich TH, Luger A, Zeyda M, Gastaldelli A, Buettner C, Scherer T.

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis. Nat Commun. 2019 Jun 20;10(1):2717.

DOI: 0.1038/s41467-019-10684-1

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Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis.

Morganti C, Missiroli S, Lebiedzinska-Arciszewska M, Ferroni L, Morganti L, Perrone M, Ramaccini D, Occhionorelli S, Zavan B, Wieckowski MR, Giorgi C.

Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis. Int J Obes (Lond). 2019 May;43(5):963-973.

DOI: 10.1038/s41366-018-0167-1

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Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features

Beleza J, Albuquerque J, Santos-Alves E, Fonseca P, Santocildes G, Stevanovic J, Rocha-Rodrigues S, Rizo-Roca D, Ascensão A, Torrella JR, Magalhães J.

Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats' Functional, Physiological, Biochemical, and Morphological Features. Front Physiol. 2019 May 14;10:593.

DOI: 10.3389/fphys.2019.00593

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Physical Activity is Beneficial for Gallbladder Disease

Molina-Molina E, Shanmugam H, Wang DQH, Vergani L, Portincasa P. Physical Activity is Beneficial for Gallbladder Disease.

Japanese Journal of Gastroenterology and Hepatology. 2019 May; 1(1): 1-4.

DOI:

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Gastrointestinal defects in gallstone and cholecystectomized patients

Di Ciaula A, Molina-Molina E, Bonfrate L, Wang DQ, Dumitrascu DL, Portincasa P.

Gastrointestinal defects in gallstone and cholecystectomized patients. Eur J Clin Invest. 2019 Mar;49(3):e13066.

DOI: 10.1111/eci.13066

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The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile

Portincasa P, van Erpecum KJ, Di Ciaula A, Wang DQ.

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile. Gastroenterol Rep (Oxf). 2019 Feb;7(1):32-41.

DOI: 10.1093/gastro/goy044

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Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Grattagliano I, Montezinho LP, Oliveira PJ, Frühbeck G, Gómez-Ambrosi J, Montecucco F, Carbone F, Wieckowski MR, Wang DQ, Portincasa P.

Targeting mitochondria to oppose the progression of non-alcoholic fatty liver disease. Biochem Pharmacol. 2019 Feb;160:34-45.

DOI: 10.1016/j.bcp.2018.11.020

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Critical Care Aspects of Gallstone Disease

Portincasa P, Molina-Molina E, Garruti G, Wang DQ.

Critical Care Aspects of Gallstone Disease. J Crit Care Med (Targu Mures). 2019 Feb 4;5(1):6-18.

DOI: 10.2478/jccm-2019-0003

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A Mitochondrial Approach to Cardiovascular Risk and Disease

Veloso CD, Belew GD, Ferreira LL, Grilo LF, Jones JG, Portincasa P, Sardão VA, Oliveira PJ.

A Mitochondrial Approach to Cardiovascular Risk and Disease. Curr Pharm Des. 2019;25(29):3175-3194.

DOI: 10.2174/1389203720666190830163735

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Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Jarak I, Barosa C, Martins FO, Silva JCP, Santos C, Belew GD, Rito J, Viegas I, Teixeira J, Oliveira PJ, Jones JG.

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate. Magn Reson Med. 2019 Jan;81(1):639-644.

DOI: 10.1002/mrm.27378

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Rho-kinase/AMPK Axis Regulates Hepatic Lipogenesis During Overnutrition

Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung BH, Hwang D, Kim MS, Park KS, Macedo MP, White M, Jones J, Kim YB.

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. J Clin Invest. 2018 Dec 3;128(12):5335-5350.

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Molecular mechanisms and pathophysiology of ischemia-reperfusion injury

Panisello-Roselló A, Roselló-Catafau J.

Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury. Int J Mol Sci. 2018 Dec 18;19(12):4093.

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Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Duarte N, Coelho I, Holovanchuk D, Inês Almeida J, Penha-Gonçalves C, Paula Macedo M.

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells. Hepatol Commun. 2018 Sep 7;2(9):1080-1094.

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Exercising the Hepatobiliary-gut Axis. The Impact of Physical Activity Performance

Molina-Molina E, Lunardi Baccetto R, Wang DQ, de Bari O, Krawczyk M, Portincasa P. Exercising the hepatobiliary-gut axis.

The impact of physical activity performance. Eur J Clin Invest. 2018 Aug;48(8):e12958.

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Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury

Panisello-Roselló A, Alva N, Flores M, Lopez A, Castro Benítez C, Folch-Puy E, Rolo A, Palmeira C, Adam R, Carbonell T, Roselló-Catafau J.

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury. Int J Mol Sci. 2018 Aug 22;19(9):2479.

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Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Panisello-Roselló A, Lopez A, Folch-Puy E, Carbonell T, Rolo A, Palmeira C, Adam R, Net M, Roselló-Catafau J.

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update. World J Gastroenterol. 2018 Jul 21;24(27):2984-2994.

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Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution Appraisal

Panisello-Rosello A, Castro-Benítez C, Lopez A, Balloji S, Folch-Puy E, Adam R, Roselló-Catafau J.

Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution Appraisal. Transplant Proc. 2018 Apr;50(3):714-718.

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Mitochondria in Non-Alcoholic Fatty Liver Disease

Simões ICM, Fontes A, Pinton P, Zischka H, Wieckowski MR.

Mitochondria in Non-Alcoholic Fatty Liver Disease. Int J Biochem Cell Biol. 2018 Feb;95:93-99.

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Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavan B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR.

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases. Int Rev Cell Mol Biol. 2018;340:209-344.

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Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK

Panisello-Roselló A, Verde E, Lopez A, Flores M, Folch-Puy E, Rolo A, Palmeira C, Hotter G, Carbonell T, Adam R, Roselló-Catafau J.

Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK. Int J Mol Sci. 2018 Jan 24;19(2):348.

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Bile Acids and Cancer: Direct and Environmental-Dependent Effects

Di Ciaula A, Wang DQ, Molina-Molina E, Lunardi Baccetto R, Calamita G, Palmieri VO, Portincasa P.

Bile Acids and Cancer: Direct and Environmental-Dependent Effects. Ann Hepatol. 2017 Nov;16 Suppl 1:S87-S105.

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Bile Acid Physiology

Di Ciaula A, Garruti G, Lunardi Baccetto R, Molina-Molina E, Bonfrate L, Wang DQ, Portincasa P. Bile Acid Physiology. Ann Hepatol. 2017 Nov;16 Suppl 1:S4-S14.

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Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine

Grasselli E, Canesi L, Portincasa P, Voci A, Vergani L, Demori I.

Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine. Ann Hepatol. 2017 Sep-Oct;16(5):707-719.

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The color of fat and its central role in the development and progression of metabolic diseases.

Gaggini M, Carli F, Gastaldelli A.

The color of fat and its central role in the development and progression of metabolic diseases. Horm Mol Biol Clin Investig. 2017 Sep 25;31(1):/j/hmbci.2017.31.issue-1/hmbci-2017-0060/hmbci-2017-0060.xml.

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