This project will focus on the quantification of Krebs cycle fluxes in various animal models of NAFLD as well as in human Non-Alcoholic Fatty Liver Disease (NAFLD) patients, using mass spectrometry and 13C -stable isotope tracers and noninvasive “chemical biopsy” analysis of hepatic metabolite enrichments.
Research will include methodologies for assessing 13C-enrichment analysis of plasma glucose and mass spectrometry and applying these data to metabolic models of hepatic Krebs cycle and gluconeogenic fluxes.
National Research Council (CNR), Italy.
Dr. Amalia Gastaldelli
French National Institute of Health and Medical Research (INSERM), France.
Dr. Carina Prip-Buus