A key objective of the FOIE GRAS network is to better understand the metabolic mechanisms and treatment behind Non-Alcoholic Fatty Liver Disease (NAFLD). This project aims to use animal models of postoperative hepatic failure (PHF) to measure end-points of mitochondrial function (e.g. respiration, membrane potential, oxidative stress and mitochondrial gene expression) at different points after surgery in order to predict success or failure of the surgery process.
Research will include methodologies and techniques in liver surgery in rodent models, miRNA/mtDNA and bacterial DNA screening, high throughput mitochondrial function analyses, as well as provide IR fingerprint in serum by IR-based methods.
Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC), Spain
Dr. Juan Catafau
German Research Center for Environmental Health (HMGU), Germany
Center for Neuroscience and Cell Biology (CNC), Portugal
Dr. Hans Zischka
Dr. Carlos Palmeira
Dr. Paulo Oliveira